Researchers of BBD BioPhenix-Biobide, company integrated in Bionaturis Group, has made an study for the pharmaceutical laboratory Sanofi in order to help them to confirm that some proteins present in hypoxic cells have an important function in the tumor growth. The result of the essay has recently been published in the well-regarded specialized magazine ‘The Journal of Biological Chemistry’.

The formation of new vessels in the tumor (angiogenesis) is essential for primary tumor growth and facilitates tumor invasion and metastasis. Hypoxia has been described as one trigger of angiogenesis. Indeed, hypoxia is a hallmark of solid tumors and has profound effects on the different components of the tumoral environment. For example, hypoxia is able to activate endothelial cells, leading to angiogenesis. In this study, they were identified some proteins involved in the hypoxia correlated with tumors, and the function of the identified sialoglycoproteins was assessed in a vasculogenesis assay in vivo in zebrafish by using morpholinos.

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