One of the current challenges of BBD BioPhenix (acquired by Bionaturis) is gaining position in other markets different from pharmaceutical or veterinarian ones. The versatility of its services and the high capability of its  facilities to the tailor made requirements of its customers  make BBD an essential partner in drug discovery research for other sectors such as agrochemical, petrochemical, cosmetics and nutraceutical.

“We are already working in interesting projects outside the pharmaceutical arena thanks to the suitable features of the zebra fish model for active ingredients screening and our intention is going on this track”, R&D manager Arantza Muriana, states. BBD has a zebrafish facility able to grow up to 20,000 adults, including different lines that allow developing general and organ-specific toxicity and efficacy assays. In its lab, BBD is capable of developing biological and molecular assays under robust automatization processes.

BBD zebrafish

“Nowadays, biotechnology can be applied to very different sectors and its more and more presence in our daily life”, the manager adds.

In case of BBD, the regulatory framework of the main markets is becoming an ally. Besides including the use of the zebrafish as a model in the guidelines for toxicity assays in chemical, agrochemical and cosmetic products, the limitations in the use of animals models for experimental assays are increasing (in accordance to the 3-R’s Rules: Replacement, Reducement and Refinement). These new guidelines do not exclude the use of zebrafish, because it is not considered as a superior animal model in these situations as long as the assays are made with embryos aged up to five days old. In this way, the use of the zebrafish model is becoming one of the alternatives with more applications.

Find below some of the OECD Guidelines including zebrafish as an alternative model:

– OECD 203. Fish Acute Toxicity Test

– OECD 210. Fish, Early-life Stage Toxicity Test

– OECD 212. Fish, Short-term Toxicity Test on Embryo and Sac-fry Stages

– OECD 229. Fish Short Term Reproduction Assay

– OECD 236. Fish Embryo Acute Toxicity (FET) Test